Sigma-Aldrich, based in St. Louis, is one of the largest producers and distributors of chemicals and laboratory equipment worldwide. Founded in 1934 the company Sigma was merged in 1976 with the company Aldrich to form the global corporation Sigma-Aldrich.

Grade Definitions & Common Applications

Puriss p.a.
Applications: Specialized or Sensitive Chemical Synthesis & Catalysis, Reaction Monitoring, Metal-Sensitive Reactions, Highly Sensitive Purifications

These high-quality solvents offer specifications that match or exceed existing regulations and undergo stringent metals testing. They are the optimal choice for demanding regulated applications that require quality documentation, and for impurity-sensitive reactions or extractions.

ACS Grade
Applications: Routine Chemical Synthesis, Drying & Purification, Critical Labware Cleaning

ACS solvents meet or exceed the high standards of the American Chemical Society (ACS), with test specifications that are specialized to every compound. Ideal for most research needs, these high-quality solvents deliver replicable, publishable results.

ReagentPlus® Grade
Applications: Trial Synthesis, Initial Extraction, General Chemical Synthesis, Purification, Cleaning

With a guaranteed purity ≥98.5%, ReagentPlus® solvents are ideal for trial synthesis, preparation, experiments that need fewer specifications, or applications that require innovative solutions not yet defined by ACS (e.g. our emerging green solvent line). They are primarily defined by assay specifications, and offer suitable quality for general lab use.

Reagent Grade
Applications: General Chemical Synthesis, Purification & Cleaning

Defined by assay profile and offering ≥95% purity, Reagent Grade solvents are the perfect choice for very general lab applications, such as cleaning.